Acetonitrile → (1-Aminoethylidene)bisphosphonic acid
反応式
[C:1](#[N:3])[CH3:2].[P:4]([OH:7])([OH:6])[OH:5]>O>[NH2:3][C:1]([P:4]([OH:7])([OH:6])=[O:5])([P:4]([OH:7])([OH:6])=[O:5])[CH3:2]参加物
4
反応条件
- 温度
- 150 °C
実験手順
A 1 liter autoclave was charged with a mixture of acetonitrile (61.5 g, 1.5 moles), ISOPAR-M (300 g), and the wetting agents (7.5 g each). The mixture was pressurized with nitrogen and heated to 150° C. Melted phosphorous acid (246 g, 3.0 moles) was pumped into the reactor through 15 minutes. The reaction was continued for 3 hours, maintaining the temperature at 150° C. Water (300 g) was pumped in and the product was collected after cooling. Colorless crystals of 1-amino-1,1-diphosphono ethane was obtained as fine grains, 76% yield.
後処理
- temperaturemaintaining the temperature at 150° C
- customwas collected
- temperatureafter cooling
出典と根拠
- ORDレコード
- ord-16848652c6ca43a0af0b41f16c8c096c
- 出典データセット
- uspto-grants-1978_07
- 特許番号
- US04100167
反応ノート
読み込み中…