Hydrazine hydrate (1:1) → 2-Oxazolemethanamine, 5-(4-chlorophenyl)-, monohydrochloride

HRID 866853ノート

反応式

HRID 866853 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH2:13][N:14]3C(=O)C4=CC=CC=C4C3=O)=[N:10][CH:9]=2)=[CH:4][CH:3]=1.O.NN>C(O)C>[ClH:1].[NH2:14][CH2:13][C:11]1[O:12][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:9][N:10]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 22762753HCID 22762753、化合物

生成物 1

HCID 30492642-Oxazolemethanamine, 5-(4-chlorophenyl)-, monohydrochloride収率 154.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3.4 g of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide and 0.55 g of 100% hydrazine hydrate in 50 ml of ethanol was heated at reflux for one hour. At the end of this period, the formed precipitate was filtered off, and the filtrate was evaporated to dryness in vacuo. The residue was shaken with 2N HCl - chloroform and the 2N HCl - layer was evaporated to dryness under vacuo. The residue was recrystallized from ethanol to give 1.9 g (78 percent) of 2-aminomethyl-5-(4-chlorophenyl) oxazole hydrochloride, M.P. 200° C (decomposition).

後処理

  1. temperatureat reflux for one hour
  2. filtrationAt the end of this period, the formed precipitate was filtered off
  3. customthe filtrate was evaporated to dryness in vacuo
  4. customthe 2N HCl - layer was evaporated to dryness under vacuo
  5. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-e9312d285a2d4482a7353beb8ea8e34e
出典データセット
uspto-grants-1978_07
特許番号
US04101660

反応ノート

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