Pyrrolidine → 1-(4-(Pyrrolidin-1-ylsulfonyl)phenyl)ethanone
反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]([C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=1)(=[O:8])[CH3:7]>>[C:6]([C:9]1[CH:10]=[CH:11][C:12]([S:15]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:17])=[O:16])=[CH:13][CH:14]=1)(=[O:8])[CH3:7]参加物
3
実験手順
A solution of 500 ml. of 50% aqueous pyrrolidine is treated in portions with 30.0 g. of 4-acetylbenzenesulfonyl chloride and the solution is stirred at room temperature for 1 hour. The resulting mixture is cooled to 0°-5° C. and the precipitated 1-(4-acetylbenzenesulfonyl)pyrrolidine is collected by filtration, washed with water and dried; m.p. 138°-139° C. after crystallizations from aqueous methanol and from 2-propanol.
後処理
- temperatureThe resulting mixture is cooled to 0°-5° C.
- filtrationthe precipitated 1-(4-acetylbenzenesulfonyl)pyrrolidine is collected by filtration
- washwashed with water
- customdried
- customm.p. 138°-139° C. after crystallizations from aqueous methanol
出典と根拠
- ORDレコード
- ord-82a381e053ea4e448ea044ada0add055
- 出典データセット
- uspto-grants-1978_07
- 特許番号
- US04101661
反応ノート
読み込み中…