(Dicyclopropylmethyl)amine → N-(2-Chloroethyl)-N'-(dicyclopropylmethyl)thiourea
反応式
[Cl:1][CH2:2][CH2:3][N:4]=[C:5]=[S:6].[CH:7]1([CH:10]([NH2:14])[CH:11]2[CH2:13][CH2:12]2)[CH2:9][CH2:8]1>O1CCCC1>[CH:7]1([CH:10]([NH:14][C:5]([NH:4][CH2:3][CH2:2][Cl:1])=[S:6])[CH:11]2[CH2:13][CH2:12]2)[CH2:9][CH2:8]1参加物
4
実験手順
9.2 g of β-chloroethyl isothiocyanate dissolved in 20 ml tetrahydrofuran are added dropwise to a solution of 9 g of dicyclopropylmethylamine in 70 ml tetrahydrofuran. The reaction mixture is kept at a temperature of from 0° to +5° C. during the addition, then maintained at room temperature for 2 hours. The solvent is evaporated to dryness and the residue, consisting essentially of N-(1,1-dicyclopropylmethyl) N'-(β-chloroethyl) thiourea, is recovered and used without any further purification for the next step of the synthesis.
後処理
- additionThe reaction mixture is kept at a temperature of from 0° to +5° C. during the addition
- customThe solvent is evaporated to dryness
- customis recovered
- customused without any further purification for the next step of the synthesis
出典と根拠
- ORDレコード
- ord-57c8f27a13e747fe90500f455dbce454
- 出典データセット
- uspto-grants-1978_07
- 特許番号
- US04102890
反応ノート
読み込み中…