Potassium Carbonate → [2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-(4-trifluoromethylbenzyl)-amine

HRID 8672

反応式

HRID 8672 の反応式
Br[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2[C:15]3[S:16][CH:17]=[CH:18][C:14]=3[O:13][N:12]=2)[CH:8]=[CH:9][CH:10]=1.C(=O)([O-])[O-].[K+].[K+].[F:25][C:26]([F:36])([F:35])[C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=1>C(#N)C>[O:13]1[C:14]2[CH:18]=[CH:17][S:16][C:15]=2[C:11]([C:7]2[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=2)[O:4][CH2:3][CH2:2][NH:32][CH2:31][C:30]2[CH:29]=[CH:28][C:27]([C:26]([F:25])([F:35])[F:36])=[CH:34][CH:33]=2)=[N:12]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 768044-(Trifluoromethyl)benzylamineHCID 219835823-[3-(2-Bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

生成物 1

HCID 21983567[2-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-(4-trifluoromethylbenzyl)-amine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 4-(trifluoromethyl)benzylamine and acetonitrile essentially as described above in example 18 except that the reaction is run overnight and the compound is purified by column chromatography using a solvent gradient of 5% ethyl acetate in dichloromethane to 10% methanol in ethyl acetate. Purity by LC/MS (APCI)=98%, [M+H]+=419.

後処理

  1. customthe compound is purified by column chromatography

出典と根拠

ORDレコード
ord-9c9f9bf27da0426b8c2c143da023701a
出典データセット
uspto-grants-2006_08
特許番号
US07091199B1

関連ノート

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