Piperidine → HCID 178431711、化合物

反応式

C1CCNCC1.CC1(C)OC(=O)C(Oc2ccc(Br)cn2)=C1c1ccc(S(C)(=O)=O)cc1>CS(C)=O.O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>CC1(C)OC(=O)C(Oc2ccc(N3CCCCC3)cn2)=C1c1ccc(S(C)(=O)=O)cc1

参加物

反応条件

温度: 80 °C

後処理

additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
aliquot25 microliter of resulting solution is taken
additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

出典と根拠

ORDレコード: ord-7314f4d46d7e42f98083f8f49240c053
出典データセット: Figure 4 from Chemistry informer libraries
DOI: 10.1039/C5SC04751J
元リンク: 出典を表示

反応ノート

読み込み中…

参加物

反応物 2

HCID 8082Piperidine

HCID 99328283-((5-Bromopyridin-2-yl)oxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

生成物 1

HCID 178431711HCID 178431711、化合物収率 15.6%

試薬・触媒・溶媒 4

HCID 62657Potassium Phosphate, Tribasic試薬

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒

HCID 1188645142-[3,5-Bis(trifluoromethyl)anilino]-2-oxo-acetic acid触媒

HCID 679Dimethyl Sulfoxide溶媒2 回

反応条件

温度: 80 °C

後処理

additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
aliquot25 microliter of resulting solution is taken
additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

出典と根拠

ORDレコード: ord-7314f4d46d7e42f98083f8f49240c053
出典データセット: Figure 4 from Chemistry informer libraries
DOI: 10.1039/C5SC04751J
元リンク: 出典を表示

反応ノート

読み込み中…