Thionyl Chloride → 2-(Pentyloxy)propanoyl chloride

HRID 867357ノート

反応式

HRID 867357 の反応式
[CH2:1]([O:6][CH:7]([CH3:11])[C:8](O)=[O:9])[CH2:2][CH2:3][CH2:4][CH3:5].S(Cl)([Cl:14])=O>>[CH2:1]([O:6][CH:7]([CH3:11])[C:8]([Cl:14])=[O:9])[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 14693035HCID 14693035、化合物

生成物 1

HCID 146930362-(Pentyloxy)propanoyl chloride

実験手順

10 ml of thionyl chloride was added to 2.0 g of α-pentyloxypropionic acid and the mixture was refluxed under heat for 2 hours. Excess of thionyl chloride was distilled off to obtain α-pentyloxypropionic acid chloride. 20 ml of dry pyridine was added thereto, and 7.0 g of 5-decyl-2-(4-hydroxyphenyl)pyrimidine dissolved in 50 ml of dry benzene was further added dropwise. After the addition, the mixture was refluxed under heat, charged into ice water and extracted with benzene. The extractwas purified with a silica gel column chromatography to obtain 5-decyl-2-(4'-α-pentyloxypropanoyloxyphenyl)pyrimidine.

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureunder heat for 2 hours
  3. distillationExcess of thionyl chloride was distilled off

出典と根拠

ORDレコード
ord-dfa858b29963415888de7889351e7c5a
出典データセット
uspto-grants-1988_10
特許番号
US04775223

反応ノート

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