Dimethylformamide → HCID 67601003、化合物

HRID 867605

反応式

HRID 867605 の反応式
[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].CN(C=O)C>C(O)C>[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].[CH2:7]([OH:8])[CH3:6]

参加物

4

反応物 2

HCID 6228DimethylformamideHCID 27447Cephalexin

生成物 1

HCID 67601003HCID 67601003、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A slurry of 47.4 g of cephalexin bis-DMF solvate in 600 ml of 3A ethanol (K.F=0.03%) was stirred at room temperature and seeded with a few milligrams of a product from an earlier like preparation. After stirring the mixture 5 hours at room temperature, the ethanol in the mixture was evaporated until the total weight of the resulting slurry was 230 g. Filtration provided a crystalline cephalexin ethanol solvate. Air drying the product overnight, provided 35.1 g of crystalline desolvated cephalexin ethanolate.

後処理

  1. customearlier like preparation
  2. customthe ethanol in the mixture was evaporated until the total weight of the resulting slurry
  3. filtrationFiltration

出典と根拠

ORDレコード
ord-dfcfa13629f24651a61be0a0ae541ddf
出典データセット
uspto-grants-1988_10
特許番号
US04775751

関連ノート

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