2,6-Dibromopyridine → 2-Chloro-6-hydrazinopyridine

HRID 867624ノート

反応式

HRID 867624 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][NH2:9])[N:3]=1.BrC1C=CC=C(Br)N=1.FC1C=CC=C(NN)N=1.FC1C=CC=C(F)N=1.N(C1C=CC=C(C(F)(F)F)N=1)N.[Cl:47]C1C=CC=C(C(F)(F)F)N=1.N(C1C=NC=C(C(F)(F)F)C=1)N.FC1C=NC=C(C(F)(F)F)C=1.N(C1C(Cl)=C(Cl)N=C(Cl)C=1Cl)N.ClC1N=C(Cl)C(Cl)=C(Cl)C=1Cl>>[Cl:47][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][NH2:9])[N:3]=1

参加物

11

反応物 10

HCID 122742,6-DibromopyridineHCID 16584PentachloropyridineHCID 739342,6-DifluoropyridineHCID 6023342-Chloro-6-(trifluoromethyl)pyridineHCID 14753322-Fluoro-6-hydrazinylpyridineHCID 125021922,3,5,6-Tetrachloro-4-hydrazinylpyridineHCID 133393842-Hydrazinyl-6-(trifluoromethyl)pyridineHCID 193925882-Bromo-6-hydrazinopyridineHCID 199371823-Fluoro-5-(trifluoromethyl)pyridineHCID 212903553-Hydrazinyl-5-(trifluoromethyl)pyridine

生成物 1

HCID 3200042-Chloro-6-hydrazinopyridine

実験手順

The following were prepared analogously and analyzed by nmr spectroscopy: 2-bromo-6-hydrazinopyridine, m.p. 112°-114° C. (from 2,6-dibromopyridine); 2-fluoro-6-hydrazinopyridine, m.p. 74°-76° C. (from 2,6-difluoropyridine); 2-hydrazino-6-(trifluoromethyl)pyridine, m.p. 62°-64° C. (from 2-chloro-6-(trifluoromethyl)pyridine; 3-hydrazino-5-(trifluoromethyl)pyridine, pale yellow solid (from 3-fluoro-5-(trifluoromethyl)pyridine); 4-hydrazino-2,3,5,6-tetrachloropyridine, m.p. 180°-181° C. (from pentachloropyridine).

後処理

  1. customThe following were prepared analogously

出典と根拠

ORDレコード
ord-ec4c141d29554380a65f8fe83f303f12
出典データセット
uspto-grants-1988_10
特許番号
US04775762

反応ノート

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