Sodium Hydroxide → HCID 14306132、化合物
反応式
B(Br)(Br)Br.C[O:6][CH2:7][C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1.[OH-].[Na+]>ClCCl>[OH:6][CH2:7][C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1参加物
5
実験手順
Boron tribromide (6.1 ml) was added dropwise to a stirred solution of 2-methoxymethyl-4-piperidinopyrimidine (3.35 g) in dichloromethane (60 ml) at 0°-5° under nitrogen. After a further 30 minutes the mixture was poured onto ice, the pH raised to 13 (NaOH) and extracted with chloroform. The combined extracts were dried (K2CO3) and the volume reduced. Ether was added to give 2-hydroxymethyl-4-piperidino-pyrimidine (2.78 g) as a crystalline solid, m.p. 92°-3°.
後処理
- additionAfter a further 30 minutes the mixture was poured onto ice
- extractionextracted with chloroform
- dry with materialThe combined extracts were dried (K2CO3)
- additionEther was added
出典と根拠
- ORDレコード
- ord-01776aac310f4150985e9f039c00c48d
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04777172
反応ノート
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