Water → 4-(Dimethylaminomethyl)-2-thiophenemethanol

HRID 867920ノート

反応式

HRID 867920 の反応式
[OH:1][CH2:2][C:3]1[S:7][CH:6]=[C:5]([C:8]([N:10]([CH3:12])[CH3:11])=O)[CH:4]=1.[H-].[Al+3].[H-].[H-].O>O1CCCC1.Cl>[CH3:12][N:10]([CH2:8][C:5]1[CH:4]=[C:3]([CH2:2][OH:1])[S:7][CH:6]=1)[CH3:11]

参加物

6

反応物 3

HCID 962WaterHCID 212890685-(Hydroxymethyl)-N,N-dimethyl-3-thiophenecarboxamideHCID 21584524Aluminiumhydride

生成物 1

HCID 129265384-(Dimethylaminomethyl)-2-thiophenemethanol

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 5-(hydroxymethyl)-N,N-dimethyl-3-thiophenecarboxamide (1.7 g) in dry tetrahydrofuran (150 ml) was treated with a 0.5M solution of aluminium hydride in tetrahydrofuran (26 ml). After 2 h at room temperature, water (5 ml) was cautiously added and the mixture was filtered through diatomaceous earth. The filtrate was evaporated to leave an oily residue, which was dissolved in 2M hydrochloric acid (20 ml). The aqueous solution was washed with diethyl ether, basified with 5M sodium hydroxide and extracted with ethyl acetate.

後処理

  1. filtrationthe mixture was filtered through diatomaceous earth
  2. customThe filtrate was evaporated
  3. customto leave an oily residue, which
  4. washThe aqueous solution was washed with diethyl ether
  5. extractionextracted with ethyl acetate

出典と根拠

ORDレコード
ord-83da7cd5e98f4b96a1597a8bf33d8a48
出典データセット
uspto-grants-1988_10
特許番号
US04777179

反応ノート

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