Pyridine → N-[[[1-(6-Fluoro-2-naphthalenylmethyl)-4-piperidinyl]amino]carbonyl]-6-quinoline carboxamide

HRID 868214

反応式

HRID 868214 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](Cl)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[F:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([NH:32][C:33]([NH2:35])=[O:34])[CH2:28][CH2:27]1)[CH:19]=[CH:18]2.N1C=CC=CC=1>ClCCCl>[F:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([CH2:25][N:26]1[CH2:27][CH2:28][CH:29]([NH:32][C:33]([NH:35][C:11]([C:7]3[CH:6]=[C:5]4[C:10](=[CH:9][CH:8]=3)[N:1]=[CH:2][CH:3]=[CH:4]4)=[O:12])=[O:34])[CH2:30][CH2:31]1)[CH:19]=[CH:18]2

参加物

5

反応物 3

HCID 1049PyridineHCID 12391963Quinoline-6-carbonyl chlorideHCID 21288076N-[[(6-fluoro-2-naphthalenyl)methyl]-4-piperidinyl]urea

生成物 1

HCID 13853618N-[[[1-(6-Fluoro-2-naphthalenylmethyl)-4-piperidinyl]amino]carbonyl]-6-quinoline carboxamide

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

A mixture of 6-quinolinoyl chloride (4.77 g, 22 mmol), N-[[(6-fluoro-2-naphthalenyl)methyl]-4-piperidinyl]urea (6.02 g, 20 mmol), dry pyridine (2.5 ml) and 1,2-dichloroethane (30 ml) is stirred at reflux for 18 hours. The solution is then cooled, washed with aqueous sodium carbonate solution, dried and evaporated. The residue is crystallised from ethanol to give the title compound, mp 200°-201° C. (softens, maleate salt).

後処理

  1. temperatureat reflux for 18 hours
  2. temperatureThe solution is then cooled
  3. washwashed with aqueous sodium carbonate solution
  4. customdried
  5. customevaporated
  6. customThe residue is crystallised from ethanol

出典と根拠

ORDレコード
ord-fe4ffe43b4e3413780803c628c8a457f
出典データセット
uspto-grants-1988_10
特許番号
US04778802

関連ノート

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