反応式
[CH3:1][N:2]([CH3:14])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[C:5]([N+:11]([O-:13])=[O:12])[CH:4]=1.[C:15]([O:23][CH2:24][CH3:25])(=[O:22])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].N1CCCCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[CH2:20]([O:19][C:17](=[O:18])[C:16]([C:15]([O:23][CH2:24][CH3:25])=[O:22])=[CH:7][C:6]1[CH:9]=[CH:10][C:3]([N:2]([CH3:14])[CH3:1])=[CH:4][C:5]=1[N+:11]([O-:13])=[O:12])[CH3:21]参加物
実験手順
A mixture of 89 g (0.5 mol) of 4-dimethylamino-2-nitrobenzaldehyde [H. Baumann, et al German Pat. 2,363,458], 237 g (1.4 mol) of diethyl malonate, 3.44 g (40.4 mmol) of piperidine and 2.43 g (40.4 mmol) of acetic acid in 400 mL of toluene was refluxed for 16 hours under argon, with a Dean Stark trap attached. The solution was cooled to room temperature and washed with 200 mL of 5% aqueous KOH. The organic phase was separated, dried over sodium sulfate (Na2SO4), filtered, and the solvent evaporated. The dark red solid residue was dissolved in 40 mL of CH2Cl2 and 100 mL of hexane added. After standing for 1 hour, the solution was filtered to yield 10.4 g of orange crystals. Recrystallization from CH2Cl2 - hexane produced an analytical sample, m.p. 101°-102° C.
後処理
- temperaturewas refluxed for 16 hours under argon, with a Dean Stark trap
- washwashed with 200 mL of 5% aqueous KOH
- customThe organic phase was separated
- dry with materialdried over sodium sulfate (Na2SO4)
- filtrationfiltered
- customthe solvent evaporated
- dissolutionThe dark red solid residue was dissolved in 40 mL of CH2Cl2
- addition100 mL of hexane added
- filtrationthe solution was filtered
出典と根拠
- ORDレコード
- ord-d5c910ee5e9a42a48eed10b2f3fbdf7b
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04778893
関連ノート
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