Malonic Acid → 2-Propenoic acid, 3-(5-fluoro-3-pyridinyl)-
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=O)[CH:5]=[N:6][CH:7]=1.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].N1CCCCC1>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])[CH:5]=[N:6][CH:7]=1参加物
5
反応条件
- 温度
- 110 °C
実験手順
A mixture of 1.1 g of the crude 5-fluoro-3-pyridinecarbaldehyde, 1.8 g of malonic acid, 0.15 ml of piperidine, and 7 ml of pyridine is stirred at 110° C. for 2 hours. The reaction mixture is concentrated, and 20 ml of water is added. The resulting precipitate is collected and washed with cold water to give 0.5 g of the title compound.
後処理
- concentrationThe reaction mixture is concentrated
- addition20 ml of water is added
- customThe resulting precipitate is collected
- washwashed with cold water
出典と根拠
- ORDレコード
- ord-398c328f6d974241a82489a18330cfbb
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04778796
反応ノート
読み込み中…