Malonic Acid → 3-(4-Phenyl-3-pyridyl)acrylic acid
反応式
[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][C:8]=2[CH:13]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(=O)[CH2:16][C:17]([OH:19])=[O:18].N1CCCCC1.N1C=CC=CC=1>C(OCC)C>[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][C:8]=2[CH:13]=[CH:16][C:17]([OH:19])=[O:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
6
反応条件
- 温度
- 100 °C
実験手順
A mixture of 4.3 g of 4-phenyl-3-pyridinecarbaldehyde [cf. Heterocycles, 14, 813 (1980)], 2.5 g of malonic acid, 0.5 ml of piperidine, and 6 ml of pyridine is stirred at 100° C. for 2 hours. After cooling, 50 ml of diethyl ether is added, and the resulting precipitate is collected. The obtained solid is washed with water and dried to give 3.4 g of the title compound.
後処理
- temperatureAfter cooling
- customthe resulting precipitate is collected
- washThe obtained solid is washed with water
- customdried
出典と根拠
- ORDレコード
- ord-f1e2ee7d3787457791a3e82c719d748a
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04778796
反応ノート
読み込み中…