m-Chloroperbenzoic acid → HCID 178526259、化合物

HRID 868500ノート

反応式

HRID 868500 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[N:10][C:3]=12.ClC1C=CC=C(C(OO)=[O:19])C=1>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][N+:5]([O-:19])=[C:4]2[NH:8][CH:9]=[N:10][C:3]=12

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 178478247HCID 178478247、化合物

生成物 1

HCID 178526259HCID 178526259、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

7-Chloro-3H-imidazo[4,5-b]pyridine (15 g, 97.7 mMol) was dissolved in 150 mL of glacial acetic acid and m-chloroperbenzoic acid (23 g, 131 mMol) was added in portions to the stirred solution. After 12 hours the solid was isolated and washed with ether. The solid was suspended in 400 mL of hot ethanol, stirred, and isolated. The product, 7-chloro-3H-imidazo[4,5-b]pyridine-4-oxide, was dried in vacuo. Yield 14.98 g (8.83 mMol, 90.4%); m.p. 200° C. (dec).

後処理

  1. customAfter 12 hours the solid was isolated
  2. washwashed with ether
  3. customisolated
  4. dry with materialThe product, 7-chloro-3H-imidazo[4,5-b]pyridine-4-oxide, was dried in vacuo

出典と根拠

ORDレコード
ord-0a56a881bad44beea6cc96d5ffe81037
出典データセット
uspto-grants-1988_10
特許番号
US04780452

反応ノート

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