4-Chloroaniline → 2-Bromo-N-(4-chlorophenyl)propanamide
反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Br:9][CH:10]([CH3:14])[C:11](Cl)=[O:12]>ClCCl.O>[Br:9][CH:10]([CH3:14])[C:11]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:12]参加物
5
実験手順
To a solution of 4-chloroaniline (400 mg, 3.13 mmol) in anhydrous dichloromethane at room temperature under N2 was added slowly 2-bromopropanoyl chloride (474 μL, 4.7 mmol). The reaction mixture was stirred at room temperature for 2 h and then diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The organic extracts were combined, washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo to give 2-bromo-N-(4-chlorophenyl)propanamide, which was used without further purifications.
後処理
- extractionextracted with ethyl acetate (3×50 mL)
- washwashed with brine
- dry with materialdried over anhydrous MgSO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-d123a7653263404eb3407a89978a65c8
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969342B2
反応ノート
読み込み中…