N-bromobutanimide → 3-(Bromomethyl)isoquinolin-1(2H)-one

HRID 868906ノート

反応式

HRID 868906 の反応式
[CH3:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.C1C=CC(C2C=CC(C3OC(C4C=CC=CC=4)=CN=3)=CC=2)=CC=1.[Br:36]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.CCOC(C)=O>[Br:36][CH2:1][C:2]1[NH:3][C:4](=[O:12])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

6

反応物 3

HCID 67184N-bromobutanimideHCID 967282-(Biphenyl-4-yl)-5-phenyloxazoleHCID 32444773-Methyl-1,2-dihydroisoquinolin-1-one

生成物 1

HCID 700972123-(Bromomethyl)isoquinolin-1(2H)-one

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a refluxing solution of 3-methylisoquinolin-1(2H)-one (1.7 g, 10.69 mmol) and 2-(4-biphenyl)-5-phenyloxazole (120 mg) in CCl4 (30 mL) was added N-bromosuccinimide (1.9 g, 10.7 mmol) in portions. The reaction mixture was stirred at reflux for 2 h. After cooling to room temperature, the reaction mixture was diluted with EtOAc, filtered and concentrated to give the crude product, which was used for the next step without further purification. LC-MS: m/z 238 (M+H+).

後処理

  1. temperatureat reflux for 2 h
  2. filtrationfiltered
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-ea588e2b03f5477e8066257f1a425e14
出典データセット
uspto-grants-2015_03
特許番号
US08969349B2

反応ノート

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