(4-Phenyl-1,3-thiazol-2-yl)methanol → 4-Phenyl-1,3-thiazole-2-carbaldehyde
反応式
[C:1]1([C:7]2[N:8]=[C:9]([CH2:12][OH:13])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(Cl)Cl.O=[Mn]=O>[C:1]1([C:7]2[N:8]=[C:9]([CH:12]=[O:13])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
To (4-phenylthiazol-2-yl)methanol (900 mg, 4.7 mmol) in DCM (10 mL) was added MnO2 (4 g, 47 mmol), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was then filtered, washed with water, extracted with EtOAc and dried over anhydrous sodium sulfate. The solution was concentrated under vacuum to give a crude product, which was purified by column chromatography to afford the title compound as a yellow solid (360 mg).
後処理
- filtrationThe reaction mixture was then filtered
- washwashed with water
- extractionextracted with EtOAc
- dry with materialdried over anhydrous sodium sulfate
- concentrationThe solution was concentrated under vacuum
- customto give a crude product, which
- customwas purified by column chromatography
出典と根拠
- ORDレコード
- ord-4bc28a79bd7741e2969c7d22eec64782
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969349B2
反応ノート
読み込み中…