Ethyl formate → Ethyl 2-(benzyloxy)-3-oxopropanoate

HRID 869301ノート

反応式

HRID 869301 の反応式
[H-].[Na+].[CH:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:8]([O:15][CH2:16][C:17](OCC)=[O:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCOCC>[CH2:8]([O:15][CH:16]([CH:17]=[O:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 290299Ethyl 2-(benzyloxy)acetate

生成物 1

HCID 19903223Ethyl 2-(benzyloxy)-3-oxopropanoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a suspension of sodium hydride (3.3 g, 60% in paraffin oil, 82.5 mmol) in dry ether (100 mL) and dry ethyl formate (5.55 g, 75 mmol) was added ethyl (benzyloxy)acetate (14.57 g, 75 mmol) dropwise with stirring. The resulting mixture solution was then refluxed for 2 h and concentrated to give crude ethyl 2-(benzyloxy)-3-oxopropanoate which was used in the subsequent step without further purification.

後処理

  1. temperatureThe resulting mixture solution was then refluxed for 2 h
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-bf3ba2740770454b819b381849387ac0
出典データセット
uspto-grants-2015_03
特許番号
US08969364B2

反応ノート

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