Benzaldehyde → HCID 86722234、化合物

HRID 869386ノート

反応式

HRID 869386 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[Na+].O>CO>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH:2]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 962WaterHCID 14798Sodium HydroxideHCID 86722235HCID 86722235、化合物

生成物 1

HCID 86722234HCID 86722234、化合物収率 92.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
45 °C

実験手順

A mixture of 7G (1.5 g, 6.26 mmol), benzaldehyde (0.863 g, 8.14 mmol, 1.3 eq) and NaOH (1.0 g, 25.04 mmol, 4 eq) in MeOH (20 mL) was stirred at 45° C. for 24 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (20 mL) The yellow solids precipitated out were collected by filtration and dried to give product 8A (1.9 g, 92.6% yield).

後処理

  1. customthe reaction
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customprecipitated out
  4. filtrationwere collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-bfb088da04e847ed8265e7dfa61e942b
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

読み込み中…