Water → HCID 86722239、化合物

HRID 869390ノート

反応式

HRID 869390 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][CH:22]=[C:23]([CH:25]=O)[N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+].O>CO>[NH2:9][C:8]1[C:7]2[C:10]([Cl:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:25][C:23]1[N:24]=[C:20]([CH:17]([CH3:19])[CH3:18])[S:21][CH:22]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 27631922-(Propan-2-yl)-1,3-thiazole-4-carbaldehydeHCID 86722235HCID 86722235、化合物

生成物 1

HCID 86722239HCID 86722239、化合物収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
45 °C

実験手順

A mixture of 7G (6.4 g, 26.7 mmol), 2-isopropyl-thiazole-4-carbaldehyde (4.8 g, 30.92 mmol, 1.16 eq) and NaOH (4.27 g, 106.8 mmol, 4 eq) in MeOH (200 mL) was stirred at 45° C. for 24 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (200 mL) The yellow precipitates were collected by filtration and dried to give product 10A (9.96 g, 98.9% yield).

後処理

  1. customthe reaction
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customyellow precipitates
  4. filtrationwere collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-8ee97524d0b845ea82e203b6675dca9d
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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