Lithium borohydride → HCID 21914755、化合物

HRID 869396ノート

反応式

HRID 869396 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[S:9][CH:10]=1)=O)C.[Li+].[BH4-]>C1COCC1>[C:12]([NH:11][C:8]1[S:9][CH:10]=[C:6]([CH2:4][OH:3])[N:7]=1)(=[O:16])[CH:13]([CH3:15])[CH3:14]

参加物

4

反応物 2

HCID 4148881Lithium borohydrideHCID 21914754HCID 21914754、化合物

生成物 1

HCID 21914755HCID 21914755、化合物収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

11B (0.73 g, 3 mmol) was dissolved in THF (14 mL). To the solution was added LiBH4 (0.23 g, 10 mmol) in batches at room temperature. The reaction mixture was refluxed overnight, then quenched with 14 mL of anhydrous MeOH and concentrated to dryness. The residue was dissolved in dichloromethane and filtered. The filtrate was concentrated and dried to give a crude product 11C (0.48 g, 100% yield).

後処理

  1. temperatureThe reaction mixture was refluxed overnight
  2. customquenched with 14 mL of anhydrous MeOH
  3. concentrationconcentrated to dryness
  4. dissolutionThe residue was dissolved in dichloromethane
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated
  7. customdried

出典と根拠

ORDレコード
ord-9fc6cc235f2d4b5d9850ea158d98f2e9
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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