Methanol → HCID 86722258、化合物

HRID 869412ノート

反応式

HRID 869412 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Br:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][CH:22]=[C:23]([CH:25]=O)[N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+].CO>O>[NH2:9][C:8]1[C:7]2[C:10]([Br:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:25][C:23]1[N:24]=[C:20]([CH:17]([CH3:19])[CH3:18])[S:21][CH:22]=1

参加物

6

反応物 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 27631922-(Propan-2-yl)-1,3-thiazole-4-carbaldehydeHCID 86722252HCID 86722252、化合物

生成物 1

HCID 86722258HCID 86722258、化合物収率 94.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A mixture of 12G (2 g, 7 mmol), 2-isopropyl-thiazole-4-carbaldehyde (2.2 g, 14.6 mmol), NaOH (1.5 g) and MeOH (20 mL) was heated to 50° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15A (2.8 g, 94.4% yield).

後処理

  1. customreacted overnight
  2. customthe reaction
  3. filtrationThe precipitated solids were collected by filtration

出典と根拠

ORDレコード
ord-c95180d3aade4f86bd59966307b6144b
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

読み込み中…