Formamidine acetate → HCID 178518231、化合物
反応式
[NH2:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([O:9]CC)=O.C(O)(=O)C.[CH:16](N)=[NH:17]>CCO>[CH:5]1[N:4]=[C:3]2[C:7]([N:17]=[CH:16][NH:1][N:2]2[CH:6]=1)=[O:9]参加物
4
実験手順
A mixture of ethyl 1-amino-1H-imidazole-2-carboxylate (800 mg, 5.16 mmol, 1.0 eq) and formamidine acetate (2.68 g, 25.78 mmol, 5.0 eq) in EtOH (100 mL) was stirred at reflux overnight. The resulting mixture was cooled to RT. The solid was collected by filtration, rinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3), and then dried in vacuo to afford imidazo[1,2-f][1,2,4]triazin-4-ol (400 mg, 50.2% yield).
後処理
- temperatureat reflux overnight
- filtrationThe solid was collected by filtration
- washrinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-2b8f0d45791742e6a0fb29c9443ca3aa
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969363B2
反応ノート
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