Ammonia → 2-methoxy-N-[3-(methylthio)-2-nitrophenyl]acetamide

HRID 869535

反応式

HRID 869535 の反応式
[CH3:1][S:2][C:3]1[C:4]([N+:10]([O-:12])=[O:11])=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].N1C=CC=CC=1.[CH3:19][O:20][CH2:21][C:22](Cl)=[O:23].N>CC(N(C)C)=O.O.CO>[CH3:19][O:20][CH2:21][C:22]([NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([S:2][CH3:1])[C:4]=1[N+:10]([O-:12])=[O:11])=[O:23]

参加物

8

反応物 4

HCID 222AmmoniaHCID 1049PyridineHCID 96623Methoxyacetyl chlorideHCID 109761553-(Methylthio)-2-nitroaniline

生成物 1

HCID 867213652-methoxy-N-[3-(methylthio)-2-nitrophenyl]acetamide収率 91%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 31374Dimethylacetamide溶媒

実験手順

[step 2] 3-(Methylthio)-2-nitroaniline (1.0 g, 5.4 mmol) obtained in step 1 was dissolved in DMA (5.4 mL), pyridine (0.44 mL, 5.4 mmol) and 2-methoxyacetyl chloride (1.49 mL, 16 mmol) were added, and the mixture was stirred at room temperature for 2 hr. To the reaction solution were added methanol and aqueous ammonia, and the mixture was stirred at room temperature for 30 min. Water was added, and the crystals were collected by filtration, and dried to give 2-methoxy-N-[3-(methylthio)-2-nitrophenyl]acetamide (1.26 g, 91%).

後処理

  1. stirringthe mixture was stirred at room temperature for 30 min
  2. filtrationthe crystals were collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-2cc65d3a3b3a4620afaf63eea3ce3d7a
出典データセット
uspto-grants-2015_03
特許番号
US08969345B2

関連ノート

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