Methyl iodide → 3-Bromo-2-methoxy-5-methylpyridine
反応式
[Br:1][C:2]1[C:3]([OH:9])=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.I[CH3:11]>ClCCl.C(=O)([O-])[O-].[Ag+2]>[Br:1][C:2]1[C:3]([O:9][CH3:11])=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1参加物
5
実験手順
To 3-bromo-5-methylpyridin-2-ol (500 mg, 2.7 mmol) and silver carbonate (2.6 g, 9.6 mmol) suspended in dichloromethane (10 mL) was added iodomethane (0.83 mL, 13 mmol). The reaction mixture was allowed to stir at room temperature overnight. The reaction mixture was filtered through a pad of celite and the volatiles were evaporated to yield 3-bromo-2-methoxy-5-methylpyridine, which was used directly in the next step. ESI-MS m/z calc. 201.0. found 202.3 (M+1)+. Retention time 1.51 minutes.
後処理
- filtrationThe reaction mixture was filtered through a pad of celite
- customthe volatiles were evaporated
出典と根拠
- ORDレコード
- ord-87d2fd7b94f141d89814918cb66633fe
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969386B2
反応ノート
読み込み中…