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tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate → tert-butyl N-(azetidin-3-ylmethyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate | HCID 22257620 | — |
| 触媒 | Palladium hydroxide | HCID 9942167 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-butyl N-(azetidin-3-ylmethyl)carbamate | HCID 15346872 | 67.1% |
反応手順
3.4 g (9.6 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine was dissolved in 170 mL MeOH and hydrogenated over 0.30 g Pd(OH)2 at 5 MPa over night. The catalyst was filtered off and the solvent evaporated. The crude product was purified by flash chromatography using MeOH/CH2Cl2, 1/9, followed by MeOH (saturated with NH3 (g))/CH2Cl2, 1/9, as eluent to yield 1.2 g (67%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723444 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-ecbc4c566e744d9b960cfaf350b242df |
| 出典メモ | uspto-grants-1998_03 |