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HRID870

反应详情

EQUATION

反应方程式

HRID 870 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)NCC1CN(C(c2ccccc2)c2ccccc2)C1
HCID22257620

tert-Butyl {[1-(diphenylmethyl)azetidin-3-yl]methyl}carbamate

C22H28N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NCC1CNC1
HCID15346872

tert-butyl N-(azetidin-3-ylmethyl)carbamate

C9H18N2O2

收率 67.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

3.4 g (9.6 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine was dissolved in 170 mL MeOH and hydrogenated over 0.30 g Pd(OH)2 at 5 MPa over night. The catalyst was filtered off and the solvent evaporated. The crude product was purified by flash chromatography using MeOH/CH2Cl2, 1/9, followed by MeOH (saturated with NH3 (g))/CH2Cl2, 1/9, as eluent to yield 1.2 g (67%) of the title compound.

WORKUP

后处理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated
  3. customThe crude product was purified by flash chromatography