Lipoic acid → 5-(1,2-Dithiolan-3-YL)pentanoyl chloride

HRID 870284

反応式

HRID 870284 の反応式
S(Cl)([Cl:3])=O.[CH2:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)[S:8][S:7][CH2:6]1>C(Cl)Cl>[S:7]1[CH2:6][CH2:5][CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([Cl:3])=[O:16])[S:8]1

参加物

4

反応物 2

HCID 6112Lipoic acidHCID 24386Thionyl Chloride

生成物 1

HCID 579942155-(1,2-Dithiolan-3-YL)pentanoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirred solution of thionyl chloride (1.4 mL, 7.5 mmol) in CH2Cl2 (30 ml) at 0° C. was added a solution of lipoic acid (3.0 g, 5 mmol), dissolved in dichloromethane, dropwise over 1 h. The mixture was allowed to stir for additional 3 h. at the same temperature. After completion of the reaction the solvent was removed under vacuum using a dry-ice collection trap being very careful not to heat the reaction mixture since this will decompose the product. Reaction proceeds with quantitative yield.

後処理

  1. customAfter completion of the reaction the solvent
  2. customwas removed under vacuum
  3. customa dry-ice collection trap
  4. temperatureto heat the reaction mixture since
  5. customReaction

出典と根拠

ORDレコード
ord-7db339e89ef343b4a22a7d0cf2e8d423
出典データセット
uspto-grants-2015_03
特許番号
US08969549B2

関連ノート

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