Iodoethane → 2-Bromophenetole
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].I[CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][CH3:11]参加物
5
実験手順
Into a 500-mL round-bottom flask was placed CH3COCH3 (200 mL), 2-bromophenol (10.38 g, 60.00 mmol, 1.00 equiv), iodoethane (28.08 g, 180.04 mmol, 3.00 equiv) and potassium carbonate (33.12 g, 239.64 mmol, 3.99 equiv). The resulting solution was heated to reflux overnight in an oil bath. The solids were filtered out. The filtrate was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:100). Purification afforded 11.48 g (95%) of 1-bromo-2-ethoxybenzene as a colorless oil.
後処理
- customInto a 500-mL round-bottom flask was placed
- temperatureThe resulting solution was heated
- temperatureto reflux overnight in an oil bath
- filtrationThe solids were filtered out
- concentrationThe filtrate was concentrated under vacuum
- customPurification
出典と根拠
- ORDレコード
- ord-c41bb86b516b4a38ad60daf8e2dc2224
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969557B2
反応ノート
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