Iodoethane → 2-Bromophenetole

HRID 870466

反応式

HRID 870466 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].I[CH2:10][CH3:11].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][CH3:11]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 72442-BromophenolHCID 11430Potassium Carbonate

生成物 1

HCID 685002-Bromophenetole収率 95.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Into a 500-mL round-bottom flask was placed CH3COCH3 (200 mL), 2-bromophenol (10.38 g, 60.00 mmol, 1.00 equiv), iodoethane (28.08 g, 180.04 mmol, 3.00 equiv) and potassium carbonate (33.12 g, 239.64 mmol, 3.99 equiv). The resulting solution was heated to reflux overnight in an oil bath. The solids were filtered out. The filtrate was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:100). Purification afforded 11.48 g (95%) of 1-bromo-2-ethoxybenzene as a colorless oil.

後処理

  1. customInto a 500-mL round-bottom flask was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight in an oil bath
  4. filtrationThe solids were filtered out
  5. concentrationThe filtrate was concentrated under vacuum
  6. customPurification

出典と根拠

ORDレコード
ord-c41bb86b516b4a38ad60daf8e2dc2224
出典データセット
uspto-grants-2015_03
特許番号
US08969557B2

関連ノート

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