3,4-dihydro-2H-pyran → 2-Methyl-3-(oxan-2-yloxy)propan-1-ol

HRID 870475

反応式

HRID 870475 の反応式
[CH3:1][CH:2]([CH2:5][OH:6])[CH2:3][OH:4].[O:7]1[CH:12]=[CH:11][CH2:10][CH2:9][CH2:8]1>CC1C=CC(S(O)(=O)=O)=CC=1>[CH3:1][CH:2]([CH2:5][O:6][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][O:7]1)[CH2:3][OH:4]

参加物

4

反応物 2

HCID 80803,4-dihydro-2H-pyranHCID 75103Methylpropanediol

生成物 1

HCID 122906532-Methyl-3-(oxan-2-yloxy)propan-1-ol収率 66.6%

試薬・触媒・溶媒 1

HCID 6101p-Toluenesulfonic acid触媒

実験手順

Into a 50-mL 3-necked round-bottom flask was placed 2-methylpropane-1,3-diol (20 g, 221.92 mmol, 1.00 equiv) and 4-methylbenzene-1-sulfonic acid (11 mg, 0.06 mmol). Then 3,4-dihydro-2H-pyran (5 g, 59.44 mmol, 0.27 equiv) was added at 0° C. The resulting solution was stirred for 3 h at room temperature. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:20). Purification afforded 6.9 g (18%) of 2-methyl-3-(oxan-2-yloxy)propan-1-ol as a light yellow liquid.

後処理

  1. customInto a 50-mL 3-necked round-bottom flask was placed
  2. customPurification

出典と根拠

ORDレコード
ord-692be86c9ba44a3b8ae9639c85a13f43
出典データセット
uspto-grants-2015_03
特許番号
US08969557B2

関連ノート

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