Sodium hydride → HCID 86696429、化合物
反応式
Br[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[N:12]2[N:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]2=[N:10][CH:9]=1)=[O:6].[H-].[Na+]>CN(C=O)C.CCOC(C)=O>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]2[N:12]([C:8]([N:7]3[CH2:2][CH2:3][CH2:4][C:5]3=[O:6])=[CH:9][N:10]=2)[N:13]=1参加物
5
実験手順
To 1.0 g of 4-bromo-N-(6-chloroimidazo[1,2-b]pyridazin-3-yl)butanamide (3.15 mmol) dissolved in 39 mL DMF was added NaH (189 mg, 4.72 mmol), and stirred at rt for 0.5 hr. Dilute with 50 mL EtOAc and separate the organic layer. Wash twice with water, once with brine and dry over MgSO4. Concentrate to obtain the product 0.49 g (66%). No purification was needed.
後処理
- customseparate the organic layer
- washWash twice with water, once with brine
- dry with materialdry over MgSO4
- concentrationConcentrate
出典と根拠
- ORDレコード
- ord-ef82852c93bb478197d76aa645b46d71
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969565B2
反応ノート
読み込み中…