Hydrochloric Acid → 4-{[({4-(Aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoic acid

HRID 871010ノート

反応式

HRID 871010 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:22]([C:23]([NH2:25])=[O:24])=[C:21]([NH:26][C:27]([N:29]4[CH2:33][CH2:32][CH2:31][C:30]4=[O:34])=[O:28])[S:20][N:19]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:4][CH:3]=1.Cl.[OH-:36].[Na+]>>[NH2:25][C:23]([C:22]1[C:18]([C:15]2[CH:16]=[CH:17][C:12]([NH:11][C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=3)=[O:10])=[CH:13][CH:14]=2)=[N:19][S:20][C:21]=1[NH:26][C:27]([NH:29][CH2:33][CH2:32][CH2:31][C:30]([OH:34])=[O:36])=[O:28])=[O:24]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 716216293-[4-({[(4-Methylphenyl)amino]carbonyl}amino)phenyl]-5-{[(2-oxopyrrolidin-1-yl)carbonyl]amino}isothiazole-4-carboxamide

生成物 1

HCID 866892284-{[({4-(Aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoic acid

実験手順

3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]-5-{[(2-oxopyrrolidin-1-yl)carbonyl]amino}isothiazole-4-carboxamide (11.8 g,) was added to 1 N sodium hydroxide (100 mL) at ambient temperature. The resulting mixture was stirred at ambient temperature for overnight (reaction mixture became clear solution). Reaction mixture acidified with 2 N HCl. The solid which formed was collected by filtration and washed with water then dried in vacuo to give the title compound as off white solid (9.1 g, 75%).

後処理

  1. custom(reaction mixture became clear solution)
  2. customReaction mixture
  3. customThe solid which formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customthen dried in vacuo

出典と根拠

ORDレコード
ord-38faf31f64f740be88c0ef555bfa4064
出典データセット
uspto-grants-2015_03
特許番号
US08969583B2

反応ノート

読み込み中…