Water → 4-(4-Nitroisothiazol-5-yl)morpholine

HRID 871042ノート

反応式

HRID 871042 の反応式
Br[C:2]1[S:6][N:5]=[CH:4][C:3]=1[N+:7]([O-:9])=[O:8].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.CCN(C(C)C)C(C)C.O>O1CCOCC1>[N+:7]([C:3]1[CH:4]=[N:5][S:6][C:2]=1[N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)([O-:9])=[O:8]

参加物

6

反応物 4

HCID 962WaterHCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 126311735-Bromo-4-nitroisothiazole

生成物 1

HCID 712617854-(4-Nitroisothiazol-5-yl)morpholine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 5-bromo-4-nitroisothiazole (P) (500 mg, 2.39 mmol) and morpholine (6B2) (620 mg, 7.12 mmol) in dioxane (10 mL) at room temperature (25° C.) was added DIEA (851 μL, 4.78 mmol). The solution was stirred for 30 min and HPLC showed the reaction was complete. Water (10 mL) was then added. A precipitate was formed, filtered and air dried at room temperature to get the product 6C6 (500 mg, 2.32 mmol).

後処理

  1. customA precipitate was formed
  2. filtrationfiltered
  3. customair dried at room temperature
  4. customto get the product 6C6 (500 mg, 2.32 mmol)

出典と根拠

ORDレコード
ord-1222045766594109a02eccc1ca989843
出典データセット
uspto-grants-2015_03
特許番号
US08969584B2

反応ノート

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