Risedronate → Phosphate

HRID 871802

反応式

HRID 871802 の反応式
[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:14]([OH:17])([OH:16])=[O:15])([P:10]([OH:13])([OH:12])=[O:11])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19].[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].[OH-].[Na+].C1C=NC=C(CC(P(O)(O)=O)(P(O)(O)=O)O)C=1>O>[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:10]([OH:12])([OH:13])=[O:11])([P:14]([OH:17])([OH:16])=[O:15])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19]

参加物

6

反応物 3

HCID 5245RisedronateHCID 14798Sodium HydroxideHCID 131732542HCID 131732542、化合物

生成物 2

HCID 1061PhosphateHCID 5245Risedronate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The risedronate-calcium-phosphate solution and 0.5N sodium hydroxide were simultaneously added to 100 mL water to maintain the pH at 7.00 until all the risedronate had been added. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 105° C. 3.93 g of calcium complex salt of Risedronate with phosphate were thus obtained.

後処理

  1. additionhad been added
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customThe solid was dried in an oven at 105° C

出典と根拠

ORDレコード
ord-0a522a8974974305a5371efb11cab55e
出典データセット
uspto-grants-2015_03
特許番号
US08974801B2

関連ノート

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