Sodium Hydroxide → 4-Ethylamino-2-methylthiopyrimidine-5-carboxylic acid
反応式
[CH2:1]([NH:3][C:4]1[C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][N:7]=[C:6]([S:15][CH3:16])[N:5]=1)[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([NH:3][C:4]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=[C:6]([S:15][CH3:16])[N:5]=1)[CH3:2]参加物
4
実験手順
A mixture containing 6.33 g (26.0 mmol) of ethyl 4-ethylamino-2-methylthio-5-pyrimidinecarboxylate, 65 mL (65.0 mmol) of 1N NaOH and 60 mL of ethanol is refluxed for 1 hour. The ethanol is evaporated off under reduced pressure and the residue is diluted in 100 mL of water. 65 mL of aqueous 1N HCl solution are added and the white precipitate formed is drained by suction. The solid is rinsed with water and dried under vacuum. 5.1 g of expected product are obtained in the form of a white solid. Melting point=188°C. Yield=92%.
後処理
- temperatureis refluxed for 1 hour
- customThe ethanol is evaporated off under reduced pressure
- additionthe residue is diluted in 100 mL of water
- addition65 mL of aqueous 1N HCl solution are added
- customthe white precipitate formed
- washThe solid is rinsed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-20558241aeed426fb1b3e1f0eeafe494
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975250B2
反応ノート
読み込み中…