N-Iodosuccinimide → HCID 67607194、化合物
反応式
[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([OH:14])=[CH:13][C:8]=3[N:7]=[N:6]2)[CH2:3][CH2:2]1.[I:15]N1C(=O)CCC1=O>C(O)(=O)C.O>[CH:1]1([CH2:4][N:5]2[C:9]3[CH:10]=[CH:11][C:12]([OH:14])=[C:13]([I:15])[C:8]=3[N:7]=[N:6]2)[CH2:2][CH2:3]1参加物
5
実験手順
1-(Cyclopropylmethyl)-1H-benzotriazol-5-ol (9-1, 5.41 g, 28.6 mmol) was dissolved in acetic acid (75 mL) and treated with N-iodosuccinimide (4.79 g, 21.3 mmol, 0.74 equiv) portionwise. After 15 minutes, the mixture was diluted with water (150 mL) and extracted with dichloromethane (2×100 mL). The combined organic extracts were dried with sodium sulfate, filtered and concentrated in vacuo, providing the titled compound 9-2.
後処理
- extractionextracted with dichloromethane (2×100 mL)
- dry with materialThe combined organic extracts were dried with sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-8d02a4ffa34247c5a482281108bc6c9f
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975286B2
反応ノート
読み込み中…