Lithium Hydroxide → 2-(Methylamino)-1,3-thiazole-4-carboxylic acid
反応式
[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1.[OH-].[Li+]>C1COCC1.O>[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1参加物
4
実験手順
Ethyl 2-methylamino-1,3-thiazole-4-carboxylate (300 mg, 1.611 mmol) was dissolved in THF/water mixture and 1M litium hydroxide (3.22 ml, 3.22 mmol) was added. The reaction mixture was stirred at RT for 3 hours, pH was adjusted to acidic and the mixture was evaporated to dryness to yield the title compound. 1H-NMR (400 MHz; DMSO-d6): δ 2.84 (s, 3H), 7.46 (s, 1H), 7.90 (bs, 1H).
後処理
- customwas evaporated to dryness
出典と根拠
- ORDレコード
- ord-05c1086b02a5407fb35c1773ef452e3d
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975254B2
反応ノート
読み込み中…