Lithium Hydroxide → 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid

HRID 872680

反応式

HRID 872680 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1.[OH-].[Li+]>C1COCC1.CO>[F:14][C:2]([F:1])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 20079591Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate

生成物 1

HCID 288755572-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid収率 93%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (400 mg, 1.176 mmol) was dissolved in THF/methanol mixture (9:1) and 1M lithium hydroxide (3.55 ml, 3.55 mmol) was added slowly. The reaction mixture was stirred at RT for 1 hour, pH was adjusted to 2 and the reaction mixture was extracted three times with ethyl acetate. Ethyl acetate phases were combined, dried and evaporated to dryness. Yield 93%. m/z [197.1+1]

後処理

  1. extractionthe reaction mixture was extracted three times with ethyl acetate
  2. customdried
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-3cb7e4741a9e40bfbd87db20081dc1ec
出典データセット
uspto-grants-2015_03
特許番号
US08975254B2

関連ノート

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