Lithium Hydroxide → 2-Bromo-1,3-oxazole-4-carboxylic acid
反応式
[Br:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.[OH-].[Li+]>C1COCC1.CO.O>[Br:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1参加物
5
実験手順
Ethyl 2-bromo-1,3-oxazole-4-carboxylate (2.5 g, 11.36 mmo) was dissolved in THF/methanol mixture (9:1) and 1M lithium hydroxide (22.73 ml, 22.73 mmol) was added slowly. The reaction mixture was stirred at RT for 1 h, diluted with water and pH was adjusted to 2. Formed precipitate was filtered and dried to yield the title compound (1.1 g). The filtrate was extracted three times with ethyl acetate. Ethyl acetate phases were combined, dried and evaporated to dryness to yield the title compound 0.85 g. Total yield 88%. m/z [192.0+1]
後処理
- customFormed precipitate
- filtrationwas filtered
- customdried
出典と根拠
- ORDレコード
- ord-9e4626c765a940a78beff153896bfcd0
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975254B2
反応ノート
読み込み中…