Sodium Hydroxide → 5-Bromo-3-fluoropyridine-2-carboxylic acid
反応式
[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([C:8](N)=[O:9])=[N:6][CH:7]=1.[OH-:12].[Na+]>Cl>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([C:8]([OH:12])=[O:9])=[N:6][CH:7]=1参加物
4
実験手順
5-Bromo-3-fluoropicolinamide (1.44 g, 6.5 mmol) was stirred at 120° C. in conc. HCl (17 mL) for 1.5 h. The mixture was cooled in an ice bath and the pH adjusted to pH 5 with NaOH solution (48%, aq.). The mixture was extracted with 40% MeOH in DCM, dried using a phase separator and concentrated in vacuo to give a brown powder.
後処理
- temperatureThe mixture was cooled in an ice bath
- extractionThe mixture was extracted with 40% MeOH in DCM
- customdried
- concentrationconcentrated in vacuo
- customto give a brown powder
出典と根拠
- ORDレコード
- ord-2fddfdba1d38444eadd3b8888a19eba1
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975406B2
反応ノート
読み込み中…