(S)-3-(5-(1-methylpyrrolidin-2-yl)pyridin-3-yl)acrylonitrile → (S)-3-(5-(1-methylpyrrolidin-2-yl)pyridin-3-yl)propanenitrile
反応式
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]#[N:16])[CH:10]=[N:11][CH:12]=1>CO.[Pd]>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[C:7]1[CH:8]=[C:9]([CH2:13][CH2:14][C:15]#[N:16])[CH:10]=[N:11][CH:12]=1参加物
4
実験手順
(S)-3-(5-(1-Methylpyrrolidin-2-yl)pyridin-3-yl)acrylonitrile (preparation 2) (185 mg, 0.87 mmol) and 5% Pd/C (50 mg) in MeOH (5 mL) were stirred under an atmosphere of hydrogen for 72 hours. The reaction mixture was filtered through Celite then the solvent evaporated. The crude product was purified by flash chromatography (5% [20% ammonia in MeOH] in DCM) to give the title compound as a pale yellow oil (141 mg, 75%).
後処理
- filtrationThe reaction mixture was filtered through Celite
- customthe solvent evaporated
- customThe crude product was purified by flash chromatography (5% [20% ammonia in MeOH] in DCM)
出典と根拠
- ORDレコード
- ord-1eb61d0a62c54ee99e5831e557af821f
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08980276B2
反応ノート
読み込み中…