Ethyl[(pyridin-3-yl)methyl]amine → N-ethyl-N-(3-pyridinylmethyl)-2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

HRID 874200

反応式

HRID 874200 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]3[C:17]=2[CH2:18][C:19](O)=[O:20])=[CH:4][CH:3]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH:29][CH2:30][CH3:31])[CH:23]=1>>[ClH:1].[CH2:30]([N:29]([CH2:28][C:24]1[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=1)[C:19](=[O:20])[CH2:18][C:17]1[N:11]2[CH:12]=[CH:13][C:14]([CH3:16])=[CH:15][C:10]2=[N:9][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH3:31]

参加物

3

反応物 2

HCID 4716480Ethyl[(pyridin-3-yl)methyl]amineHCID 18545713HCID 18545713、化合物

生成物 1

HCID 56591518N-ethyl-N-(3-pyridinylmethyl)-2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride収率 69.5%

実験手順

According to the method of Example 14, 2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(3-pyridinylmethyl)ethylamine were used as raw materials for synthesis, to obtain light yellow solid powder, yield 69.5%. m.p. 236-238° C., ESI-MS m/z: 420[M+H]+, 1H NMR(D2O, 400 MHz)δ: 0.95(t, 0.7H, J=7.00 Hz), 1.11(t, 2.3H, J=7.00 Hz), 2.39(s, 2.3H), 2.40(s, 0.7H), 3.27(q, 0.5H, J=7.00 Hz), 3.48(q, 1.5H, J=7.00 Hz), 4.13(s, 0.5H), 4.32(s, 1.5H), 4.60(s, 1.5H), 4.71(s, 0.5H), 7.15-7.22(m, 1H), 7.32-7.44(m, 4H), 7.51(s, 1H), 7.84(m, 1H), 8.12-8.14(m, 1H), 8.26(m, 1H), 8.52-8.53(m, 2H).

後処理

  1. customwere used as raw materials for synthesis
  2. customto obtain light yellow solid powder, yield 69.5%

出典と根拠

ORDレコード
ord-d659d9292a7440109b145e10b031cf36
出典データセット
uspto-grants-2015_03
特許番号
US08980887B2

関連ノート

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