Dichloromethane → 1-methyl-4-(6-methylpyridin-2-yl)-1H-pyrazole-5-carbonyl chloride

HRID 874371ノート

反応式

HRID 874371 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].C(Cl)Cl.[CH3:10][N:11]1C(C(O)=O)=[C:14]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=2)[CH:13]=[N:12]1>CN(C)C=O>[CH3:10][N:11]1[C:1]([C:2]([Cl:4])=[O:3])=[C:14]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=2)[CH:13]=[N:12]1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 903829831-methyl-4-(6-methyl-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

生成物 1

HCID 903834571-methyl-4-(6-methylpyridin-2-yl)-1H-pyrazole-5-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Oxalyl chloride (0.85 ml) was added to a mixed solution of methylene chloride (5 ml) and N,N-dimethylformamide (5 μl) containing the 1-methyl-4-(6-methylpyridin-2-yl)-1H-pyrazole-5-carboxylic acid (210 mg) obtained in (Example 3.3) <Step 1>, and the obtained mixture was then stirred for 2 hours. Thereafter, the reaction solution was concentrated under reduced pressure to obtain a crude product (230 mg) of the title compound in the form of an orange solid.

後処理

  1. customobtained in (Example 3.3) <Step 1>
  2. concentrationThereafter, the reaction solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d764705d3a2143639d6df1641108f711
出典データセット
uspto-grants-2015_03
特許番号
US08980888B2

反応ノート

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