Sodium Hydroxide → 7-Chloro-2-methyl-1H-pyrrolo[2,3-C]pyridine
反応式
[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[C:9]([CH3:11])[N:8](S(C3C=CC=CC=3)(=O)=O)[C:7]=12.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=12参加物
4
実験手順
To a solution of 7-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine (220 mg, 0.71 mmol) in ethanol (10 mL), a solution of sodium hydroxide (10%, 6 mL) was added and the reaction mixture was stirred at room temperature for about 16 hours. The solvent was removed under vacuum. The residue was taken up in ethyl acetate washed with water and brine, dried over anhydrous sodium sulfate & concentrated under vacuum to give 7-chloro-2-methyl-1H-pyrrolo[2,3-c]pyridine (110 mg, 92% yield).
後処理
- customThe solvent was removed under vacuum
- washwashed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-fb55c381f7f246e2b02d4e4932adcc3c
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08980911B2
反応ノート
読み込み中…