benzyl 4-[(methoxycarbonyl)amino]-1H-pyrrolo[3,2-c]pyridine-1-carboxylate → methyl 1H-pyrrolo[3,2-c]pyridin-4-ylcarbamate
反応式
[CH3:1][O:2][C:3]([NH:5][C:6]1[C:11]2[CH:12]=[CH:13][N:14](C(OCC3C=CC=CC=3)=O)[C:10]=2[CH:9]=[CH:8][N:7]=1)=[O:4]>C(O)C.[Pd]>[NH:14]1[C:10]2[CH:9]=[CH:8][N:7]=[C:6]([NH:5][C:3](=[O:4])[O:2][CH3:1])[C:11]=2[CH:12]=[CH:13]1参加物
4
実験手順
To a stirred solution of benzyl 4-[(methoxycarbonyl)amino]-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (264 mg, 0.82 mmol, Step a) in ethanol (10 mL) was added catalytic amount of palladium on carbon (10% wet). The reaction mixture was stirred under an atmosphere of hydrogen gas (atmospheric pressure) for 1 hour. The reaction mixture was filtered over celite and the residue washed with ethanol. The filtrate was concentrated to yield methyl 1H-pyrrolo[3,2-c]pyridin-4-ylcarbamate as a white powder (141 mg, 90.75%).