Nitric Acid → HCID 60205312、化合物

HRID 875670ノート

反応式

HRID 875670 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.[N+:12]([O-])([OH:14])=[O:13]>O>[F:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[C:11]([N+:12]([O-:14])=[O:13])[C:3]=12

参加物

4

反応物 2

HCID 944Nitric AcidHCID 534382594,5-Difluoro-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 60205312HCID 60205312、化合物収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine (0.63 g, 4.09 mmol) was added slowly to fuming nitric acid (8.18 mL, 164 mmol) at 0° C. and stirred slowly for 5 minutes. Ice (20 g) was added followed by water (40 mL). The solid formed was collected by filtration to give 4,5-difluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (0.65 g, 80% yield) as a solid.

後処理

  1. customThe solid formed
  2. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-f80f4d4d16724959b5328049166cad0b
出典データセット
uspto-grants-2015_03
特許番号
US08981085B2

反応ノート

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