3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 60205314、化合物
反応式
Cl.[C:2](Cl)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.[F:11][C:12]1[C:17]([F:18])=[CH:16][N:15]=[C:14]2[NH:19][CH:20]=[C:21]([NH2:22])[C:13]=12>N1C=CC=CC=1>[F:11][C:12]1[C:17]([F:18])=[CH:16][N:15]=[C:14]2[NH:19][CH:20]=[C:21]([NH:22][C:2](=[O:9])[C:3]3[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=3)[C:13]=12参加物
4
実験手順
Nicotinoyl chloride hydrochloride (0.70 g, 3.90 mmol) was added to 4,5-difluoro-1H-pyrrolo[2,3-b]pyridin-3-amine (0.22 g, 1.30 mmol) in pyridine (5 mL). The reaction was stirred at room temperature for 10 minutes, and then the pyridine was removed. THF (5 mL) and 2N LiOH (3 mL) were added, and the reaction was stirred for 20 minutes. The THF was removed, and water (20 mL) was added. The solid formed was collected by filtration and dried to give N-(4,5-difluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)nicotinamide (0.33 g, 92% yield) as a solid.