Benzyl 3-[(tert-butoxycarbonyl)amino]-3-methylpyrrolidine-1-carboxylate → tert-butyl N-(3-methylpyrrolidin-3-yl)carbamate

HRID 875745ノート

反応式

HRID 875745 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]1([CH3:24])[CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[CH3:24][C:9]1([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:13][CH2:12][NH:11][CH2:10]1

参加物

4

反応物 1

HCID 60205236Benzyl 3-[(tert-butoxycarbonyl)amino]-3-methylpyrrolidine-1-carboxylate

生成物 1

HCID 10798104tert-butyl N-(3-methylpyrrolidin-3-yl)carbamate収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Benzyl 3-(tert-butoxycarbonylamino)-3-methylpyrrolidine-1-carboxylate (2.00 g, 5.98 mmol) and 10% Pd/C (0.32 g, 0.30 mmol) in MeOH (20 mL) were stirred under 1 atmosphere of H2 for 1 hour. The catalyst was removed by filtration and washed with methanol. The filtrate was concentrated to give tert-butyl 3-methylpyrrolidin-3-ylcarbamate (1.15 g, 96%) as a solid.

後処理

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-2c9b73689b7042fe8dcc10fcd9ac64f7
出典データセット
uspto-grants-2015_03
特許番号
US08981085B2

反応ノート

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